医学
抗生素
囊性纤维化
抗菌剂
重症监护医学
抗生素治疗
临床试验
内科学
微生物学
生物
作者
Miquel B. Ekkelenkamp,María Díez-Aguilar,Michael M. Tunney,J. Stuart Elborn,Ad C. Fluit,Rafael Cantón
摘要
Inhaled antibiotics are a common and valuable therapy for patients suffering from chronic lung infection, with this particularly well demonstrated for patients with cystic fibrosis. However, in vitro tests to predict patient response to inhaled antibiotic therapy are currently lacking. There are indications that antimicrobial susceptibility testing (AST) may have a role in guidance of therapy, but which tests would correlate best still needs to be researched in clinical studies or animal models. Applying the principles of European Committee on Antimicrobial Susceptibility Testing methodology, the analysis of relevant and reliable data correlating different AST tests to patients' outcomes may yield clinical breakpoints for susceptibility, but these data are currently unavailable. At present, we believe that it is unlikely that standard determination of minimum inhibitory concentration will prove the best predictor.
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