乳酸脱氢酶A
糖酵解
生物
氧化磷酸化
癌症研究
PI3K/AKT/mTOR通路
安普克
细胞生物学
P70-S6激酶1
信号转导
生物化学
磷酸化
新陈代谢
蛋白激酶A
作者
Aaron Boudreau,Hans E. Purkey,A. Hitz,Kirk Robarge,David Peterson,Sharada S. Labadie,Mandy Kwong,Rebecca Hong,Min Gao,Christopher Del Nagro,Raju V. Pusapati,Shuguang Ma,Laurent Salphati,Jodie Pang,Aihe Zhou,Tommy Lai,Yingjie Li,Zhongguo Chen,BinQing Wei,Ivana Yen
标识
DOI：10.1038/nchembio.2143
摘要
The application of a potent lactate dehydrogenase (LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an AMPK–mTOR–S6K-mediated switch in utilization from glycolysis to oxidative phosphorylation.
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