Single-Cell Multi-omics Sequencing of Human Early Embryos

(Abstracted from Nat Cell Biol 2018;20:847–858) DNA methylation and chromatin states are critical epigenetic indicators in embryogenesis that have been extensively studied during mouse preimplantation development. DNA methylation dynamics and parental allele-specific DNA methylation in human preimplantation embryos have been analyzed thoroughly; however, chromatin remodeling, parental allele-specific chromatin accessibility, and interrelationships between these omics are not well understood.