喹诺酮类
药效团
癌症
化学
抗癌药物
药理学
计算生物学
抗生素
医学
内科学
生物
立体化学
生物化学
作者
Feng Gao,Xia Zhang,Tengfei Wang,Jiaqi Xiao
标识
DOI:10.1016/j.ejmech.2019.01.017
摘要
The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone derivatives possess promising anti-cancer activity, and some of them have already been approved to treat cancers or under clinical trials. Hybridization of quinolone with other anti-cancer pharmacophores may provide more efficient anti-cancer candidates, so quinolone hybrids worth to be investigated. In this review, the recent advances in the development of novel quinolone hybrids as potential anti-cancer agents are highlighted, and the structure-activity relationship is also discussed to provide an insight for further development of more active quinolone hybrids.
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