Bile acid sequestrant colesevelam enhances beneficial effects of brown fat activation on cholesterol metabolism in APOE*3-Leiden.CETP mice

Aim: We previously showed that brown fat activation accelerates the clearance of cholesterol-enriched remnants by the liver, thus reducing hypercholesterolemia and improving HDL functionality, consequently protecting against atherosclerosis development (Nat Commun 2015; Nat Commun 2017). Liver cholesterol is the main substrate for the synthesis of bile acids (BAs) that are secreted into the intestine and recycled via the enterohepatic circulation. Since the impact of brown fat activation on BA metabolism is still obscure, we now aimed to evaluate the effects of brown fat activation on cholesterol and BA metabolism without and with blocking the enterohepatic BA circulation.