Optimization of a single HPLC-PDA method for quantifying Metformin, Gliclazide, Pioglitazone, Dapagliflozin, Empagliflozin, Saxagliptin, Linagliptin and Teneligliptin using central composite design

• Optimization of a single HPLC method using CCD for the assay of 8 antidiabetic drugs. • Validation of the method as per the ICH guidelines. • Application of the method for the assay of all the FDC’s of the 8 antidiabetic drugs.