溶剂
膜
微生物
有机溶剂
膜蛋白
生物化学
化学
功能(生物学)
运输机
细菌
生物
细胞生物学
化学工程
基因
遗传学
工程类
作者
Peng Ren,Lei Ai,Fangwei Mei
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2023-02-01
卷期号:30 (2): 137-145
被引量:1
标识
DOI:10.2174/0929866530666221226100221
摘要
Background: Solvent tolerance is a desired feature of microorganisms for their application in biotechnology. Organic solvent-tolerant microorganisms are able to thrive in the presence of organic solvents. Several mechanisms have been proposed to elucidate their intrinsic tolerance to organic solvents. Objective: Membrane proteins related to transporter, signal transduction, and material and energy metabolism are involved in solvent tolerance. Optimization of the expression level of membrane proteins and engineering of membrane proteins are utilized to tackle the toxicity caused by organic solvents. Results: Membrane proteins related to transporter, signal transduction, and material and energy metabolism are involved in solvent tolerance. Optimization of the expression level of membrane proteins and engineering of membrane proteins are utilized to tackle the toxicity caused by organic solvents. Conclusions: Membrane proteins occupy a strikingly important position in microbial solvent tolerance. Further research on novel methods in membrane proteins, trade-offs among overexpression and toxicity of membrane proteins and solvent yield, and a direct relationship between signaling pathways and solvent tolerance will advance the utilization of organic solvent-tolerant microorganisms in biotechnology.
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