心脏毒性
槲皮素
药理学
阿霉素
心功能曲线
医学
肌钙蛋白I
氧化应激
体内
抗氧化剂
化学
毒性
心力衰竭
化疗
内分泌学
内科学
生物化学
生物
生物技术
心肌梗塞
作者
Patricia Lorena Dulf,Camelia Alexandra Coadǎ,Adrian Florea,Remus Moldovan,Ioana Bâldea,Daniel Vasile Dulf,Dan Blendea,Gabriela Adriana Filip
出处
期刊:Antioxidants
[MDPI AG]
日期:2024-08-31
卷期号:13 (9): 1068-1068
标识
DOI:10.3390/antiox13091068
摘要
Doxorubicin (DOX) is an effective anticancer drug, but its use is limited by dose-dependent heart toxicity. Quercetin is a natural antioxidant frequently studied for its beneficial properties. Moreover, a wide range of dietary supplements are available for human use. This in vivo study aimed to explore the potential cardioprotective effects of quercetin in chronic DOX treatment. A total of 32 Wistar rats were randomly divided into four groups: control, DOX, DOX/Q-50, and DOX/Q-100, treated with saline, 2.5 mg/kg body-weight DOX, 2.5 mg/kg body-weight DOX + 50 mg quercetin, and 2.5 mg/kg body-weight DOX + 100 mg quercetin, respectively, for two weeks. Rats were monitored using cardiac ultrasound (US) and markers for cardiac injury. Oxidative damage and ultrastructural changes in the heart were investigated. Chronic DOX treatment led to a decline in cardiac function and elevated values of NT pro-BNP, troponin I, and CK-MB. Quercetin treatment slightly improved certain US parameters, and normalized serum NT pro-BNP levels. Furthermore, DOX-induced SOD1 depletion with consequent Nrf2 activation and DNA damage as shown by an increase in γH2AX and 8HOdG. Quercetin treatment alleviated these alterations. Oral administration of quercetin alleviated serum markers associated with DOX-induced cardiotoxicity. Furthermore, it exhibited a favorable impact on the cardiac US parameters. This suggests that quercetin may have potential cardioprotective properties.
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