化学
对偶(语法数字)
生物物理学
生物化学
纳米技术
组合化学
艺术
材料科学
文学类
生物
作者
Henan Zhang,Changsheng Chen,Jingjun Han,Shuaishuai Wang,Qingwen Jia,Peixue Ling,Shuang Li,Junqiang Fang
标识
DOI:10.1016/j.bioorg.2024.107816
摘要
In this work, we developed a dual-targeting probe consisted of well-defined hyaluronan (HA) oligosaccharide and glucose (Glc) labeled with Rhodamine B (HGR). The probe was designed to enhance tumor targeting both in vitro and in vivo, by simultaneously targeting CD44 and Glc transporter 1 (GLUT1). The HA oligosaccharide component was crucial for accurately assessing the impact of sugar chain structure on targeting efficacy, while its unoccupied carboxyl groups could minimize interference with HA's binding affinity to CD44. In vitro studies demonstrated that HGR possessed remarkable cytocompatibility and superior targeting abilities compared to single-targeting probes. It displayed a marked preference for CD44
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