医学
肺动脉
心力衰竭
内科学
心脏病学
肺动脉环扎术
纤维化
动脉
血压
作者
Rei Ukita,Wei Wu,Jiancong Liang,Jennifer R. Talackine,Yatrik J. Patel,Sean A. Francois,Nancy L. Cardwell,Charles R. Flynn,Alexandra Shingina,M. Kay Washington,Vincent Q. Trinh,Matthew Bacchetta,Sophoclis P. Alexopoulos
标识
DOI:10.1152/japplphysiol.00473.2022
摘要
We present here a large animal platform for congestive hepatopathy, a disease growing in clinical prevalence due to the increasing number of Fontan-palliated patients. Further data are needed to develop a better clinical management strategy for this poorly characterized patient population. Previous reports of animal models to study this disease have mostly been in small animals with limited fidelity. We show that congestive hepatopathy can be replicated in a chronic, progressive pulmonary artery banding model in sheep. We also show that the banding strategy can be controlled to titrate the level of liver injury. To date, we do not know of any other large animal model that can achieve this level of control over disease phenotype and clinical relevance.
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