Pharmacokinetic and Bioequivalent Study of Potassium Chloride Sustained‐Release Tablet Under Different Dietary Conditions in Healthy Chinese Subjects

生物等效性 药代动力学 医学 交叉研究 尿 排泄 药理学 内科学 化学 替代医学 有机化学 病理 安慰剂
作者
Qin Li,Zhuan Yang,Shijing Liu,Lin Liu,Lü Chen,Qian Zhang,Yan Zhou,Peng Du,Chen Zeng,Na Li,Yan Zeng,Yun Xiong,Di Jia Liu,Jiyu Chen,Yan He
出处
期刊:Clinical pharmacology in drug development [Wiley]
卷期号:12 (3): 267-272 被引量:1
标识
DOI:10.1002/cpdd.1180
摘要

Potassium (K+ ) is an endogenous substance that is an essential dietary component. However, the interaction between dietary arrangements and specific effects of dietary K+ intake in bioequivalence studies remains unclear. To investigate the influence of dietary arrangement on the bioequivalence of potassium chloride (KCl) sustained-release tablets in healthy Chinese volunteers, the pharmacokinetics of KCl were compared in two open-label, single-center, randomized, two-period crossover studies with different dietary conditions. All volunteers received an oral dose of 6 g of KCl sustained-release tablets under fasting conditions, with different dietary arrangements. Urine samples were collected on baseline days and 48 hours after tablet consumption. Inductively coupled plasma-optical emission spectrometry was used to measure the concentration of K+ in the urine samples. Pharmacokinetic parameters were analyzed using Phoenix WinNonlin software in a noncompartmental model. In either clinical trial, no significant differences were observed in the maximal rate of urinary excretion and cumulative urinary excretion from 0 to 24 hours of K+ between the reference and test drugs. The bioequivalence studies of both KCl sustained-release tablet formulations were successfully conducted under different dietary conditions.
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