神经调节
不利影响
医学
神经刺激
经颅直流电刺激
动物研究
脑刺激
临床试验
随机对照试验
神经影像学
恶心
神经科学
心理学
刺激
麻醉
精神科
内科学
作者
Penny P.I. Qin,Minxia Jin,Annie Xia,Ami Sin Man Li,Tim Tian Ze Lin,Yuchen Liu,Rebecca L.D. Kan,Bella Zhang,Georg S. Kranz
标识
DOI:10.1016/j.neubiorev.2023.105501
摘要
Low-intensity transcranial ultrasound stimulation (LITUS) is a novel non-invasive neuromodulation technique. We conducted a systematic review to evaluate current evidence on the efficacy and safety of LITUS neuromodulation. Five databases were searched from inception to May 31, 2023. Randomized controlled human trials and controlled animal studies were included. The neuromodulation effects of LITUS on clinical or pre-clinical, neurophysiological, neuroimaging, histological and biochemical outcomes, and adverse events were summarized. In total, 11 human studies and 44 animal studies were identified. LITUS demonstrated therapeutic efficacy in neurological disorders, psychiatric disorders, pain, sleep disorders and hypertension. LITUS-related changes in neuronal structure and cortical activity were found. From histological and biochemical perspectives, prominent findings included suppressing the inflammatory response and facilitating neurogenesis. No adverse effects were reported in controlled animal studies included in our review, while reversible headache, nausea, and vomiting were reported in a few human subjects. Overall, LITUS alleviates various symptoms and modulates associated brain circuits without major side effects. Future research needs to establish a solid therapeutic framework for LITUS.
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