高氨血症
医学
重症监护医学
尿素循环
病因学
急诊科
重症监护
呼吸窘迫
儿科
人口
脑水肿
内科学
精神科
麻醉
化学
氨基酸
精氨酸
环境卫生
生物化学
作者
Christina R. Rojas,Jennifer Chapman,Debra S. Regier
出处
期刊:Pediatric emergency care
[Ovid Technologies (Wolters Kluwer)]
日期:2024-01-31
卷期号:40 (2): 156-161
被引量:1
标识
DOI:10.1097/pec.0000000000003121
摘要
Abstract Hyperammonemia is a serious clinical condition associated with significant morbidity and mortality. In the pediatric population, this is often caused by urea cycle disorders, acute liver failure, or other less common underlying etiologies. Children and teens with hyperammonemia can have a broad range of clinical findings, including vomiting, respiratory distress, and changes in mental status. As ammonia levels worsen, this presentation can progress to respiratory failure, encephalopathy, cerebral edema, seizures, and death. Given the risk of neurologic damage, timely identification and management of hyperammonemia is critical and includes initial resuscitation, early consultation with subspecialists, and initiation of appropriate therapies. It is important for pediatric emergency medicine providers to understand the clinical findings, causes, diagnosis, and management of hyperammonemia because they play a key role in the provision of effective, multidisciplinary care of these patients.
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