医学
血友病
入射(几何)
儿科
疾病
关节病
关节病
滑膜炎
关节炎
物理疗法
外科
内科学
关节炎
病理
替代医学
骨关节炎
物理
光学
作者
Yoko Mizoguchi,Chihiro Tani,Mika Aizawa,Keita Tomioka,Maiko Shimomura,Shiho Nishimura,Yoshiko Matsubara,Daisuke Iwaki,Kiyoto Tanaka,Hiroshi Kawaguchi,Yuko Nakashima,Yukio Mikami,Satoshi Okada,Masao Kobayashi
出处
期刊:Haemophilia
[Wiley]
日期:2023-08-28
卷期号:29 (5): 1359-1365
被引量:1
摘要
Abstract Introduction Joint health is one of the most important factors contributing to a healthy life in patients with haemophilia. Recent study revealed that starting early prophylaxis was not enough to prevent joint disease in most paediatric patients with haemophilia. Aim In this study, we aimed to determine the age‐specific incidence of acute joint disease during childhood at single haemophilia treatment centre (HTC). Method The joint health in 48 patients was evaluated based on consecutive US testing for 5 years at annual multidisciplinary comprehensive care. Results During the study period, 23 patients (47.9%) had no joint disease since the initial examination, whereas 13 patients (27.0%) showed development from negative to positive findings. The incidence of joint disease increased with age: 0% in preschool, 5.3% in elementary school, 14.3% in junior high school and 35% beyond high school age. Among the 13 patients who developed joint disease, two experienced acquired synovitis that resolved during the follow‐up period. Statistical analysis revealed that the patients who routinely underwent follow‐up by the HTC exhibited a significantly lower incidence of joint disease than did those followed up at other institutions ( p < .001). Conclusion These results indicated that close check‐up, including routine joint examination using US as well as frequent assessment of pharmacokinetic profile at the HTC, might play an important role in avoiding joint disease among paediatric patients with haemophilia.
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