Gestational Glucose Intolerance and Birth Weight–Related Complications

医学 妊娠期糖尿病 胎龄 产科 出生体重 体质指数 糖耐量试验 妊娠期 怀孕 优势比 内科学 糖尿病 内分泌学 胰岛素抵抗 遗传学 生物
作者
Jacqueline Maya,Daryl J. Selen,Tanayott Thaweethai,Sarah Hsu,Devika Godbole,Carolin C. M. Schulte,Kaitlyn James,Sarbattama Sen,Anjali J Kaimal,Marie‐France Hivert,Camille E. Powe
出处
期刊:Obstetrics & Gynecology [Lippincott Williams & Wilkins]
卷期号:142 (3): 594-602
标识
DOI:10.1097/aog.0000000000005278
摘要

OBJECTIVE: To evaluate the risks of large-for-gestational-age birth weight (LGA) and birth weight–related complications in pregnant individuals with gestational glucose intolerance, an abnormal screening glucose loading test result without meeting gestational diabetes mellitus (GDM) criteria. METHODS: In a retrospective cohort study of 46,989 individuals with singleton pregnancies who delivered after 28 weeks of gestation, those with glucose loading test results less than 140 mg/dL were classified as having normal glucose tolerance. Those with glucose loading test results of 140 mg/dL or higher and fewer than two abnormal values on a 3-hour 100-g oral glucose tolerance test (OGTT) were classified as having gestational glucose intolerance. Those with two or more abnormal OGTT values were classified as having GDM. We hypothesized that gestational glucose intolerance would be associated with higher odds of LGA (birth weight greater than the 90th percentile for gestational age and sex). We used generalized estimating equations to examine the odds of LGA in pregnant individuals with gestational glucose intolerance compared with those with normal glucose tolerance, after adjustment for age, body mass index, parity, health insurance, race and ethnicity, and marital status. In addition, we investigated differences in birth weight–related adverse pregnancy outcomes. RESULTS: Large for gestational age was present in 7.8% of 39,685 pregnant individuals with normal glucose tolerance, 9.5% of 4,155 pregnant individuals with gestational glucose intolerance and normal OGTT, 14.5% of 1,438 pregnant individuals with gestational glucose intolerance and one abnormal OGTT value, and 16.0% of 1,711 pregnant individuals with GDM. The adjusted odds of LGA were higher in pregnant individuals with gestational glucose intolerance than in those with normal glucose tolerance overall (adjusted odds ratio [aOR] 1.35, 95% CI 1.23–1.49, P <.001). When compared separately with pregnant individuals with normal glucose tolerance, those with either gestational glucose intolerance subtype had higher adjusted LGA odds (gestational glucose intolerance with normal OGTT aOR 1.21, 95% CI 1.08–1.35, P <.001; gestational glucose intolerance with one abnormal OGTT value aOR 1.77, 95% CI 1.52–2.08, P <.001). The odds of birth weight–related adverse outcomes (including cesarean delivery, severe perineal lacerations, and shoulder dystocia or clavicular fracture) were higher in pregnant individuals with gestational glucose intolerance with one abnormal OGTT value than in those with normal glucose tolerance. CONCLUSION: Gestational glucose intolerance in pregnancy is associated with birth weight–related adverse pregnancy outcomes. Glucose lowering should be investigated as a strategy for lowering the risk of these outcomes in this group.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
2秒前
充电宝应助NVLEKU采纳,获得10
2秒前
3秒前
3秒前
天天快乐应助zhu采纳,获得10
4秒前
IRer79发布了新的文献求助10
4秒前
量子星尘发布了新的文献求助10
4秒前
麦丰完成签到,获得积分10
4秒前
4秒前
likke完成签到,获得积分20
5秒前
5秒前
FashionBoy应助li采纳,获得10
6秒前
6秒前
SciGPT应助薛定谔的猫采纳,获得10
6秒前
7秒前
7秒前
muming完成签到,获得积分20
8秒前
sanlunainiu发布了新的文献求助10
8秒前
林博研完成签到,获得积分20
8秒前
FashionBoy应助风趣的灵枫采纳,获得10
9秒前
10秒前
yihuiqing发布了新的文献求助10
11秒前
likke发布了新的文献求助10
11秒前
嗝嗝发布了新的文献求助10
11秒前
小兔狸花昕完成签到,获得积分20
12秒前
IRer79完成签到,获得积分10
14秒前
彭于晏应助noah采纳,获得10
14秒前
青年才俊发布了新的文献求助10
14秒前
zhu发布了新的文献求助10
15秒前
波波蛋完成签到,获得积分10
15秒前
16秒前
17秒前
18秒前
maguodrgon发布了新的文献求助10
21秒前
科研通AI5应助shell采纳,获得80
21秒前
波波蛋发布了新的文献求助10
21秒前
22秒前
九鹤完成签到,获得积分10
22秒前
jsy完成签到,获得积分10
22秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
By R. Scott Kretchmar - Practical Philosophy of Sport and Physical Activity - 2nd (second) Edition: 2nd (second) Edition 666
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4941339
求助须知:如何正确求助?哪些是违规求助? 4207390
关于积分的说明 13077624
捐赠科研通 3986257
什么是DOI,文献DOI怎么找? 2182529
邀请新用户注册赠送积分活动 1198125
关于科研通互助平台的介绍 1110387