Gestational Glucose Intolerance and Birth Weight–Related Complications

医学 妊娠期糖尿病 胎龄 产科 出生体重 体质指数 糖耐量试验 妊娠期 怀孕 优势比 内科学 糖尿病 内分泌学 胰岛素抵抗 遗传学 生物
作者
Jacqueline Maya,Daryl J. Selen,Tanayott Thaweethai,Sarah Hsu,Devika Godbole,Carolin C. M. Schulte,Kaitlyn James,Sarbattama Sen,Anjali J Kaimal,Marie‐France Hivert,Camille E. Powe
出处
期刊:Obstetrics & Gynecology [Ovid Technologies (Wolters Kluwer)]
卷期号:142 (3): 594-602
标识
DOI:10.1097/aog.0000000000005278
摘要

OBJECTIVE: To evaluate the risks of large-for-gestational-age birth weight (LGA) and birth weight–related complications in pregnant individuals with gestational glucose intolerance, an abnormal screening glucose loading test result without meeting gestational diabetes mellitus (GDM) criteria. METHODS: In a retrospective cohort study of 46,989 individuals with singleton pregnancies who delivered after 28 weeks of gestation, those with glucose loading test results less than 140 mg/dL were classified as having normal glucose tolerance. Those with glucose loading test results of 140 mg/dL or higher and fewer than two abnormal values on a 3-hour 100-g oral glucose tolerance test (OGTT) were classified as having gestational glucose intolerance. Those with two or more abnormal OGTT values were classified as having GDM. We hypothesized that gestational glucose intolerance would be associated with higher odds of LGA (birth weight greater than the 90th percentile for gestational age and sex). We used generalized estimating equations to examine the odds of LGA in pregnant individuals with gestational glucose intolerance compared with those with normal glucose tolerance, after adjustment for age, body mass index, parity, health insurance, race and ethnicity, and marital status. In addition, we investigated differences in birth weight–related adverse pregnancy outcomes. RESULTS: Large for gestational age was present in 7.8% of 39,685 pregnant individuals with normal glucose tolerance, 9.5% of 4,155 pregnant individuals with gestational glucose intolerance and normal OGTT, 14.5% of 1,438 pregnant individuals with gestational glucose intolerance and one abnormal OGTT value, and 16.0% of 1,711 pregnant individuals with GDM. The adjusted odds of LGA were higher in pregnant individuals with gestational glucose intolerance than in those with normal glucose tolerance overall (adjusted odds ratio [aOR] 1.35, 95% CI 1.23–1.49, P <.001). When compared separately with pregnant individuals with normal glucose tolerance, those with either gestational glucose intolerance subtype had higher adjusted LGA odds (gestational glucose intolerance with normal OGTT aOR 1.21, 95% CI 1.08–1.35, P <.001; gestational glucose intolerance with one abnormal OGTT value aOR 1.77, 95% CI 1.52–2.08, P <.001). The odds of birth weight–related adverse outcomes (including cesarean delivery, severe perineal lacerations, and shoulder dystocia or clavicular fracture) were higher in pregnant individuals with gestational glucose intolerance with one abnormal OGTT value than in those with normal glucose tolerance. CONCLUSION: Gestational glucose intolerance in pregnancy is associated with birth weight–related adverse pregnancy outcomes. Glucose lowering should be investigated as a strategy for lowering the risk of these outcomes in this group.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大模型应助九日采纳,获得10
1秒前
陶醉信封发布了新的文献求助10
1秒前
忐忑的老虎完成签到,获得积分10
1秒前
香蕉觅云应助冷傲的涵双采纳,获得10
1秒前
李健的小迷弟应助咪nana采纳,获得10
2秒前
乐乐应助lian采纳,获得10
2秒前
百龄童发布了新的文献求助10
3秒前
3秒前
3秒前
3秒前
123完成签到 ,获得积分10
4秒前
溯a完成签到,获得积分10
4秒前
蓝色风筝发布了新的文献求助10
4秒前
小白发布了新的文献求助10
4秒前
5秒前
5秒前
yanyan发布了新的文献求助10
5秒前
5秒前
豆浆油条完成签到,获得积分10
6秒前
6秒前
狗熊完成签到,获得积分10
6秒前
KingLancet完成签到,获得积分10
6秒前
郭飒完成签到,获得积分10
6秒前
李爱国应助恩赐解脱采纳,获得10
6秒前
科目三应助111采纳,获得10
7秒前
7秒前
小马甲应助白日幻想家采纳,获得10
7秒前
ly发布了新的文献求助10
8秒前
sss发布了新的文献求助10
8秒前
慕冰蝶完成签到,获得积分20
8秒前
丰富的大地完成签到,获得积分10
9秒前
笑羽完成签到,获得积分0
9秒前
地平线完成签到,获得积分10
9秒前
9秒前
Takagi发布了新的文献求助20
10秒前
赵女士完成签到,获得积分10
10秒前
lpz完成签到 ,获得积分10
10秒前
10秒前
11秒前
默默的无敌完成签到,获得积分10
12秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3244993
求助须知:如何正确求助?哪些是违规求助? 2888606
关于积分的说明 8254294
捐赠科研通 2557053
什么是DOI,文献DOI怎么找? 1385683
科研通“疑难数据库(出版商)”最低求助积分说明 650212
邀请新用户注册赠送积分活动 626403