诱导多能干细胞
胚胎干细胞
外体
干细胞
再生(生物学)
祖细胞
再生医学
移植
干细胞疗法
微泡
细胞生物学
成体干细胞
内科学
医学
癌症研究
免疫学
生物
生物化学
小RNA
基因
作者
Roghayeh Yahyazadeh,Vafa Baradaran Rahimi,Vahid Reza Askari
出处
期刊:Life Sciences
[Elsevier]
日期:2024-06-22
卷期号:351: 122858-122858
标识
DOI:10.1016/j.lfs.2024.122858
摘要
Finding novel treatments for cardiovascular diseases (CVDs) is a hot topic in medicine; cell-based therapies have reported promising news for controlling dangerous complications of heart disease such as myocardial infarction (MI) and heart failure (HF). Various progenitor/stem cells were tested in various in-vivo, in-vitro, and clinical studies for regeneration or repairing the injured tissue in the myocardial to accelerate the healing. Fetal, adult, embryonic, and induced pluripotent stem cells (iPSC) have revealed the proper potency for cardiac tissue repair. As an essential communicator among cells, exosomes with specific contacts (proteins, lncRNAs, and miRNAs) greatly promote cardiac rehabilitation. Interestingly, stem cell-derived exosomes have more efficiency than stem cell transplantation. Therefore, stem cells induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs), cardiac stem cells (CDC), and skeletal myoblasts) and their-derived exosomes will probably be considered an alternative therapy for CVDs remedy. In addition, stem cell-derived exosomes have been used in the diagnosis/prognosis of heart diseases. In this review, we explained the advances of stem cells/exosome-based treatment, their beneficial effects, and underlying mechanisms, which will present new insights in the clinical field in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI