先天免疫系统
病毒学
车站2
寄主(生物学)
免疫
干扰素
免疫学
病毒
生物
信号转导
免疫系统
斯达
细胞生物学
遗传学
车站3
作者
Zhao Huang,Wenbo Zhang,Wenbo Zhang,Wenbo Zhang,Wenbo Zhang,Wenbo Zhang,Cuiying Kong,Zhanzhuo Mai,Wenbo Zhang,Heng Wang,Heng Wang,Cuiying Kong,Zhanzhuo Mai,Zhanzhuo Mai
标识
DOI:10.1016/j.jbc.2024.107472
摘要
African swine fever virus (ASFV) causes severe disease in domestic pigs and wild boars, seriously threatening the development of the global pig industry. Type I interferon (IFN-I) is an important component of innate immunity, inducing the transcription and expression of antiviral cytokines by activating Janus-activated kinase-signal transducer and activation of transcription (JAK-STAT) signal transduction. However, the underlying molecular mechanisms by which ASFV antagonizes IFN-I signaling have not been fully elucidated. Therefore, using co-immunoprecipitation, confocal microscopy and dual luciferase reporter assay methods, we investigated these mechanisms and identified a novel ASFV immunosuppressive protein, pB475L, which interacts with the C-terminal domain of STAT2. Consequently, pB475L inhibited IFN-I signaling by inhibiting STAT1 and STAT2 heterodimerization and nuclear translocation. Furthermore, we constructed an ASFV-B475L
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