Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease

美金刚 医学 磁共振成像 大脑大小 心理学 神经心理学 内科学 麻醉 痴呆 认知 精神科 疾病 放射科
作者
Michael W. Weiner,Carl Sadowsky,Judith Saxton,Robert K. Hofbauer,Stephen M. Graham,Sung Yun Yu,Shaoyi Li,Hai‐An Hsu,Joyce Suhy,Moshe Fridman,James L. Perhach
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:7 (4): 425-435 被引量:34
标识
DOI:10.1016/j.jalz.2010.09.003
摘要

Background This study was designed to assess changes in brain volume and cognitive abilities in memantine‐treated patients with Alzheimer's disease (AD) by using an exploratory, single‐arm, delayed‐start design. Methods Cholinesterase inhibitor‐treated patients with AD (N = 47; Mini‐Mental State Examination score range: 15–23) were enrolled in an observational lead‐in period (weeks: 1–24), followed by an open‐label period of add‐on memantine treatment (weeks: 25–48). The patients underwent magnetic resonance imaging at weeks 0 (baseline), 24 (immediately before memantine initiation), and 48 (endpoint), and a battery of neuropsychological tests at weeks 0, 24, 28, 36, and 48. The primary outcome measure was the annualized rate of change (%) in total brain volume (TBV) between the two study periods. Data were analyzed using paired t ‐tests. Results There were no statistically significant differences in the rates of change in TBV, ventricular volume, or left hippocampal volume between the study periods; however, the memantine treatment period was associated with a significantly slower right hippocampal atrophy (−5.5% ± 12.0% vs −10.8% ± 7.2%; P = .038). Memantine treatment was also associated with superior performances on the Boston Naming Test ( P = .034) and the Trail Making Test, Part B ( P = .001), but also with a higher number of errors (i.e., repetitions and intrusions) on the California Verbal Learning Test. Memantine was found to be safe and well tolerated. Conclusions In this study, no difference in the rates of TBV change between the two periods was observed; however, memantine treatment was found to be associated with slowing of right hippocampal atrophy, and with improvement on one test of executive functioning as well as a test of confrontation naming ability. Trials using structural magnetic resonance imaging and a delayed‐start design may be a feasible option for the assessment of treatments for AD.
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