肽
苯丙氨酸
细胞毒性
化学
氨基酸
毒性
淀粉样蛋白(真菌学)
活力测定
β淀粉样蛋白
BETA(编程语言)
生物化学
产量(工程)
体外
药理学
生物
有机化学
计算机科学
程序设计语言
材料科学
冶金
无机化学
作者
Margarida Cruz,Tusell J,Dolors Grillo-Bosch,Fernando Albericio,José M. Serratosa,Francesc Rabanal,Ernest Giralt
出处
期刊:Journal of Peptide Research
[Wiley]
日期:2004-03-01
卷期号:63 (3): 324-328
被引量:50
标识
DOI:10.1111/j.1399-3011.2004.00156.x
摘要
Single N-methyl amino acid-containing peptides related to the central hydrophobic region beta16-20 (Lys-Leu-Val-Phe-Phe) of the beta-amyloid protein are able to reduce the cytotoxicity of natural beta1-42 in PC12 cell cultures. N-methyl phenylalanine analogs yield statistically significant increments in cell viability (Student's t-test < 0.01%) and are nontoxic in the same assay. These promising results indicate that these peptide molecules could be a starting point for the development of potential therapeutic compounds for the treatment of Alzheimer's disease.
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