Association analysis of the variant in the regulatory subunit of phosphoinositide 3‐kinase (p85α) with Type 2 diabetes mellitus and hypertension in the Chinese Han population

医学 中国人口 蛋白质亚单位 2型糖尿病 磷酸肌醇3激酶 糖尿病 联想(心理学) 内科学 人口 内分泌学 遗传学 基因 PI3K/AKT/mTOR通路 环境卫生 信号转导 基因型 认识论 哲学 生物
作者
S. Chen,Weili Yan,Jianfeng Huang,Dongliang Ge,Zhi Yao,Dongfeng Gu
出处
期刊:Diabetic Medicine [Wiley]
卷期号:22 (6): 737-743 被引量:10
标识
DOI:10.1111/j.1464-5491.2005.01490.x
摘要

To determine whether variants in the gene for the regulatory subunit of phosphoinositide 3-kinase (p85alpha) are associated with Type 2 diabetes mellitus (Type 2 DM) and hypertension in a Chinese population.We performed a case-control study genotyping the Met326Ile and IVS4+82A>G polymorphisms in 494 patients with Type 2 DM and hypertension and 557 normal controls from the north of China. Individual genotypes were identified by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The IVS4+82A>G polymorphism was further confirmed by direct sequencing in 20 randomly selected cases.The IVS4+82A>G polymorphism that is common in Caucasians was not detected in our population. Frequencies of genotypes and alleles of Met326Ile polymorphism were not significantly different between cases and controls in whole samples by univariate analysis. Logistic regression analysis demonstrated that Ile326Ile genotype was associated with a 2.085-fold (95% CI, 1.043-4.168, P = 0.0377) relative risk of diabetes and hypertension. After stratification by obesity, the frequency of Ile326Ile genotype in cases was higher than that in controls (18/304 vs. 13/510, P = 0.015) among non-obese individuals (BMI < 28 kg/m2). We did not find that this missense mutation was associated with blood pressure, glucose and blood lipids in the control group.Our data indicate that the Met326Ile variation in the gene encoding the p85alpha protein might contribute to the increased risk of Type 2 DM and hypertension in Chinese.
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