嗜热菌
生物
嗜热菌
热
基因组
遗传学
全基因组测序
基因
耐辐射球菌
脱球菌
福斯密德
细菌
大肠杆菌
作者
Anke Henne,Holger Brüggemann,C. Raasch,Arnim Wiezer,Thomas Hartsch,Heiko Liesegang,André Johann,Tanja Lienard,Olivia Gohl,Rosa Martínez‐Arias,Carsten Jacobi,Vytaute Starkuviene,Silke Schlenczeck,Silke Dencker,Robert Huber,Hans‐Peter Klenk,Wilfried Kramer,Rainer Merkl,Gerhard Gottschalk,H J Fritz
摘要
Thermus thermophilus HB27 is an extremely thermophilic, halotolerant bacterium, which was originally isolated from a natural thermal environment in Japan. This organism has considerable biotechnological potential; many thermostable proteins isolated from members of the genus Thermus are indispensable in research and in industrial applications. We present here the complete genome sequence of T. thermophilus HB27, the first for the genus Thermus. The genome consists of a 1,894,877 base pair chromosome and a 232,605 base pair megaplasmid, designated pTT27. The 2,218 identified putative genes were compared to those of the closest relative sequenced so far, the mesophilic bacterium Deinococcus radiodurans. Both organisms share a similar set of proteins, although their genomes lack extensive synteny. Many new genes of potential interest for biotechnological applications were found in T. thermophilus HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation.
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