纳米载体
材料科学
费斯特共振能量转移
药物输送
纳米技术
介孔有机硅
介孔材料
表面改性
介孔二氧化硅
缺氧(环境)
药品
生物物理学
荧光
药理学
氧气
化学
有机化学
医学
催化作用
物理
物理化学
生物
量子力学
作者
Yingnan Liu,Lei Xie,Meng Gao,Runhao Zhang,Jingchen Gao,Jiangdong Sun,Qingdong Chai,Tong Wu,Kang Liang,Pu Chen,Qi Wan,Biao Kong
标识
DOI:10.1021/acsami.1c15067
摘要
Hypoxia, induced by inadequate oxygen supply, is a key indication of various major illnesses, which necessitates the need to develop new nanoprobes capable of sensing hypoxia environments for the targeted system monitoring and drug delivery. Herein, we report a hypoxia-responsive, periodic mesoporous organosilica (PMO) nanocarrier for repairing hypoxia damage. β-cyclodextrin (β-CD) capped azobenzene functionalization on the PMO surface could be effectively cleaved by azoreductase under a hypoxia environment. Moreover, the nanosystem is equipped with fluorescence resonance energy transfer (FRET) pair (tetrastyrene derivative (TPE) covalently attached to the PMO framework as the donor and Rhodamine B (RhB) in the mesopores as the receptor) for intracellular visualization and tracking of drug release in real-time. The design of intelligent nanocarriers capable of simultaneous reporting and treating of hypoxia conditions highlights a great potential in the biomedical domain.
科研通智能强力驱动
Strongly Powered by AbleSci AI