幽门螺杆菌
血瘀
慢性胃炎
胃炎
体内
中医药
小桶
机制(生物学)
蓼
药理学
化学
内科学
基因
医学
传统医学
基因表达
生物
病理
生物化学
遗传学
基因本体论
替代医学
哲学
认识论
作者
Xiaohan Song,Yun He,Min Liu,Ye Yang,Yan Yuan,Jiaoyan Yan,Mengwei Zhang,Jian Huang,Shu Zhang,Fei Mo
标识
DOI:10.1016/j.bioorg.2021.105044
摘要
Helicobacter pylori (H. pylori) infection is a common disease that can cause H. pylori-associated gastritis (HAG), peptic ulcers, and gastric cancer. As a traditional Chinese medicine, Polygonum capitatum (PC) manifests its unique advantages in the prevention and treatment of complex diseases and chronic diseases, due to its ability to clear heat, detoxify and relieve pain, promote blood circulation, and remove blood stasis. In order to explore the molecular mechanism of PC for HAG, the study collected the predicted targets of active compounds, conducted functional analysis by the STRING database, collected HAG differential expression genes, and conducted KEGG enrichment analysis on the intersection of predicted targets and differential expression genes of gastritis by Cluego. The results show that PC works mainly by affecting phosphorylation of IκBα, NF-κB p65, p38MAPK, and ERK1/2 and nuclear transposition of NF-κB p65 and p-p38MAPK, which has been proved by in vivo and in vitro experiments. These results suggest that PC may act on HAG with multiple targets and pathways, and play a key role in the process of HAG treatment.
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