结直肠癌
医学
萧条(经济学)
内科学
荟萃分析
斯科普斯
糖尿病
科克伦图书馆
科学网
梅德林
癌症
疾病
内分泌学
法学
经济
宏观经济学
政治学
作者
Yin Huang,Dehong Cao,Zeyu Chen,Bo Chen,Jin Li,Ruyi Wang,Jianbing Guo,Qiang Dong,Chengfei Liu,Qiang Wei,Liangren Liu
标识
DOI:10.1080/10408398.2021.1982861
摘要
Iron is an essential trace element, while excess iron can lead to different levels of physical abnormalities or diseases. This umbrella review aimed to conduct a systematic evaluation of the possible relationships between iron intake and various health outcomes. We retrieved PubMed, Embase, Web of Science, Scopus, and the Cochrane Database of Systematic Reviews from inception through May 2021. A total of 34 meta-analyses with 46 unique health outcomes were identified. Heme iron intake was positively associated with nine outcomes, including colorectal cancer, type 2 diabetes mellitus, and cardiovascular disease mortality, while dietary total iron intake could decrease the risk of colorectal adenoma, esophageal cancer, coronary heart disease, and depression. Iron supplementation was a protective factor against eight outcomes. However, it was associated with decreased length and weight gain. The quality of evidence for most outcomes was “low” or “very low” with the remaining eleven as “high” or “moderate”. All outcomes were categorized as class III, IV, or NS based on evidence classification. Although high iron intake has been identified to be significantly associated with a range of outcomes, firm universal conclusions about its beneficial or negative effects cannot be drawn given the low quality of evidence for most outcomes.
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