1,3‐Dioleoyl‐2‐palmitoyl glycerol (OPO)—Enzymatic synthesis and use as an important supplement in infant formulas

Journal of Food BiochemistryVolume 45, Issue 7 e13799 REVIEW 1,3-Dioleoyl-2-palmitoyl glycerol (OPO)—Enzymatic synthesis and use as an important supplement in infant formulas Michael Kidane Ghide, Michael Kidane Ghide orcid.org/0000-0003-2017-8044 Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Contribution: Conceptualization, Data curation, Formal analysis, Validation, Writing - original draft, Writing - review & editingSearch for more papers by this authorYunjun Yan, Corresponding Author Yunjun Yan [email protected] Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Correspondence Yunjun Yan, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. Email: [email protected] Contribution: Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing - review & editingSearch for more papers by this author Michael Kidane Ghide, Michael Kidane Ghide orcid.org/0000-0003-2017-8044 Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Contribution: Conceptualization, Data curation, Formal analysis, Validation, Writing - original draft, Writing - review & editingSearch for more papers by this authorYunjun Yan, Corresponding Author Yunjun Yan [email protected] Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Correspondence Yunjun Yan, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. Email: [email protected] Contribution: Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing - review & editingSearch for more papers by this author First published: 02 June 2021 https://doi.org/10.1111/jfbc.13799 Funding information This work was financially supported by the National Natural Science Foundation of China (No. J1103514) and the Fundamental Research Funds for HUST (Nos. 2014NY007, 2017KFYXJJ212, 2017KFXKJC010, and 2017KFTSZZ001) Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract 1,3-dioleolyl-2-palmitate (OPO) is an important component of the human milk fat. Its unique fatty acid composition and distribution play an important role in proper infant growth and development. Owing to this, it has been attracting researchers and manufacturers to synthesize and commercialize OPO as an important human milk fat substitute added to infant formulas. In this review, the role of OPO in human milk, the benefits of OPO (sn-2 palmitate)-supplemented infant formulas over the conventional infant formulas on infant growth, and lipase-catalyzed synthesis of OPO are discussed. Over the last 20 years of research on the benefits of OPO (sn2 palmitate)-supplemented infant formulas are summarized. Similarly, studies carried out on lipase catalyzed production of OPO for the last 21 years (1999–2019) are also done focusing on the raw materials, sn1,3-regiospecific lipases, immobilization materials, and solvents used in the laboratory-scale experiments. In addition, OPO-based products currently in the market and future research trends are briefly covered in this review. Practical applications This work focuses on lipase-catalyzed synthesis of 1,3-dioleoyl-2-palmitoylglycerol (the most abundant triacyl glycerol in human milk fat) and its benefits to infants when it is added in infant formulas. Over the last 20 years of published research from the literature are summarized and future research trends for efficient OPO synthesis are also covered. This will provide current and future researchers on the field with the necessary background information on OPO synthesis and design their research plans accordingly for cost-effective production of OPO and OPO-supplemented infant formulas. CONFLICT OF INTEREST The authors declare no conflict of interest. Volume45, Issue7July 2021e13799 RelatedInformation