对映选择合成
化学
烯胺
分子间力
催化作用
铜
有机化学
胺气处理
组合化学
分子
作者
Rémi Blieck,Sébastien Lemouzy,Arie van der Lee,Marc Taillefer,Florian Monnier
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-11-15
卷期号:23 (23): 9199-9203
被引量:5
标识
DOI:10.1021/acs.orglett.1c03477
摘要
We herein describe an intermolecular enantioselective α-addition of aldehydes to allenamides using a dual copper/enamine catalytic system. Highly enantioselective addition of aldehydes was obtained thanks to secondary amine catalysts. The process was found to be highly regio-, stereo-, and enantioselective under mild conditions.
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