Does Divergence Exist between Animal and Human Data on the Effect of Cebranopadol?

Editorial| September 2021 Does Divergence Exist between Animal and Human Data on the Effect of Cebranopadol? Albert Dahan, M.D., Ph.D.; Albert Dahan, M.D., Ph.D. Search for other works by this author on: This Site PubMed Google Scholar Erik Olofsen, Ph.D. Erik Olofsen, Ph.D. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information From the Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands. Accepted for publication June 15, 2021. This editorial accompanies the article on p. 482. Address correspondence to Dr. Dahan: a.dahan@lumc.nl Anesthesiology September 2021, Vol. 135, 382–383. https://doi.org/10.1097/ALN.0000000000003885 Connected Content Commentary: Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Search Site Citation Albert Dahan, Erik Olofsen; Does Divergence Exist between Animal and Human Data on the Effect of Cebranopadol?. Anesthesiology 2021; 135:382–383 doi: https://doi.org/10.1097/ALN.0000000000003885 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: animal testing, nociceptin, opioid analgesics, opioids, primates, respiratory depression, fentanyl, respiration, opioid receptor, pain management The opioid epidemic has made physicians painfully aware of the extensive and serious side-effect profile of opioids, including when used perioperatively, in the treatment of chronic pain and when abused outside of the realm of medical treatment. The variety of side effects is large, and the most devastating adverse effects include: (1) reward and liking, which may cause addiction; (2) lightheadedness, which may cause posture instability and falls; and (3) respiratory depression, which may be potentially life-threatening. Opioid-induced respiratory depression occurs when opioids are overdosed or combined with other drugs acting within the central nervous system, such as alcohol, sedatives, antidepressants and antipsychotics,1 but may also occur at “normal doses” in vulnerable individuals. The cost of the opioid epidemic is large, both at the individual level and at the socio-(macro)-economic level. Hence, it is not surprising that there is renewed interest in the development of novel opioids with the... You do not currently have access to this content.