Sarcopenia in nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality in the United States

肌萎缩 非酒精性脂肪肝 危险系数 医学 生物电阻抗分析 脂肪肝 糖尿病 全国健康与营养检查调查 疾病 比例危险模型 脂肪变性 内科学 死亡率 胃肠病学 置信区间 体质指数 人口 内分泌学 环境卫生
作者
Donghee Kim,Karn Wijarnpreecha,Keeryth K. Sandhu,George Cholankeril,Aijaz Ahmed
出处
期刊:Liver International [Wiley]
卷期号:41 (8): 1832-1840 被引量:49
标识
DOI:10.1111/liv.14852
摘要

Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) has been associated with sarcopenia. However, mortality in the setting of NAFLD‐related sarcopenia remains undefined. We aim to determine the all‐cause and cause‐specific mortality from sarcopenia among adults with NAFLD in the USA. Methods 11 065 individuals in the Third National Health and Nutrition Examination Survey were studied and linked mortality through 2015 was analysed. NAFLD was diagnosed based on presence of ultrasonographic hepatic steatosis without other known liver diseases. Sarcopenia was defined as skeletal muscle index determined by bioelectrical impedance analysis. The Cox proportional hazard model was used to assess all‐cause mortality and cause‐specific mortality, and hazard ratio (HR) adjusted for known risk factors. Results During a median follow‐up of 23 years or more, sarcopenia was associated with increased all‐cause mortality (HR 1.27, 95% confidence interval [CI] 1.11‐1.44). Only in individuals with NAFLD, sarcopenia was associated with a higher risk for all‐cause mortality, while this association was absent in those without NAFLD. Individuals with both sarcopenia and NAFLD had a higher risk for all‐cause mortality (HR 1.28 95% CI 1.06‐1.55) compared with those without sarcopenia and NAFLD. Furthermore, sarcopenia was associated with a higher risk for cancer‐ and diabetes‐related mortality among those with NAFLD. This association was not noted in those without NAFLD. Conclusion In this nationally representative sample of US adults, sarcopenia was associated with a higher risk for all‐cause, cancer‐ and diabetes‐related mortality in individuals with NAFLD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
pkaq完成签到,获得积分10
3秒前
3秒前
顺心醉蝶完成签到 ,获得积分10
3秒前
自由的过客完成签到,获得积分10
4秒前
6秒前
7秒前
8秒前
Caroline完成签到,获得积分10
9秒前
可爱的函函应助kiki采纳,获得10
10秒前
10秒前
一路高飛完成签到,获得积分10
11秒前
11秒前
Chenzhs完成签到,获得积分10
12秒前
啦啦啦啦发布了新的文献求助10
13秒前
13秒前
14秒前
桓某人发布了新的文献求助10
14秒前
英姑应助科研通管家采纳,获得10
15秒前
wanci应助科研通管家采纳,获得10
15秒前
科研通AI2S应助科研通管家采纳,获得10
15秒前
ZSQ完成签到,获得积分20
15秒前
17秒前
18秒前
18秒前
Akim应助cavendipeng采纳,获得10
18秒前
ZSQ发布了新的文献求助10
19秒前
铲铲完成签到,获得积分10
19秒前
21秒前
yanhuazi发布了新的文献求助10
22秒前
23秒前
hyq008完成签到,获得积分10
23秒前
一颗大树完成签到,获得积分10
24秒前
马哥完成签到,获得积分10
24秒前
嗯哼发布了新的文献求助10
24秒前
doctorbin完成签到 ,获得积分10
25秒前
充电宝应助超级气泡水采纳,获得150
25秒前
结实的寒梦完成签到,获得积分10
25秒前
kiki发布了新的文献求助10
26秒前
旧城旧巷等旧人完成签到 ,获得积分10
26秒前
LShi完成签到 ,获得积分10
26秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3245702
求助须知:如何正确求助?哪些是违规求助? 2889414
关于积分的说明 8257992
捐赠科研通 2557725
什么是DOI,文献DOI怎么找? 1386510
科研通“疑难数据库(出版商)”最低求助积分说明 650327
邀请新用户注册赠送积分活动 626672