阳离子聚合
阳离子脂质体
转染
化学
脂质体
细胞生物学
细胞内
信号转导
细胞
生物化学
生物物理学
生物
基因
有机化学
作者
Caroline Lonez,Michel Vandenbranden,Jean Marie Ruysschaert
标识
DOI:10.1016/j.addr.2012.05.009
摘要
Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that are classically activated by endogenous cationic compounds. The present review provides evidence that cationic liposomes activate several cellular pathways like pro-apoptotic and pro-inflammatory cascades. An improved knowledge of the relationship between the cationic lipid properties (nature of the lipid hydrophilic moieties, hydrocarbon tail, mode of organization) and the activation of these pathways opens the way to the use and design of cationic tailored for a specific application (e.g. for gene transport or as adjuvants).
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