泛素
生物
泛素结合酶
脱氮酶
计算生物学
蛋白质组
细胞生物学
泛素蛋白连接酶类
泛素连接酶
蛋白质组学
生物信息学
生物化学
基因
作者
Michael J. Clague,Claire Heride,Sylvie Urbé
标识
DOI:10.1016/j.tcb.2015.03.002
摘要
The ubiquitin system is a major coordinator of cellular physiology through regulation of both protein degradation and signalling pathways. A key building block of a systems-level understanding has been generated by global proteomic studies, which provide copy number estimates for each component. The aggregate of ubiquitin, conjugating enzymes (E1, E2, and E3s), and deubiquitylases (DUBs) represents ∼1.3% of total cellular protein. Complementary approaches have generated quantitative measurements of various ubiquitin pools and further subdivision into different ubiquitin chain topologies. Systematic studies aimed at associating specific enzymes (E2s and DUBs) with the dynamics of these different pools have also made significant progress. Here, we delineate the emerging picture of the most significant determinants of the cellular ubiquitin economy.
科研通智能强力驱动
Strongly Powered by AbleSci AI