癌变
组蛋白脱乙酰基酶
长寿
癌症
生物
SIRT6型
癌症预防
癌症研究
NAD+激酶
组蛋白
细胞应激反应
细胞生物学
基因
战斗或逃跑反应
锡尔图因
遗传学
乙酰化
生物化学
酶
作者
Eun-Joo Kim,Soo‐Jong Um
标识
DOI:10.5483/bmbrep.2008.41.11.751
摘要
Aging and cancer both occur as a result of accumulated cellular damage, and both are related to the regulation of specific genes in the damage response. Recent research has unveiled connections between the mechanisms of aging and cancer, but how to prevent the development of cancer and increase longevity remain unknown. SIRT1 (the mammalian Sir2), which has NAD(+)-dependent class III histone deacetylase activity, may be a key gene linking the modulation of cancer and aging. SIRT1 has broad biological functions in growth regulation, stress response, tumorigenesis, endocrine signaling, and extended lifespan. Here, we focus on the current knowledge regarding the role of SIRT1 in aging and cancer, and discuss the implications of SIRT1 as a therapeutic target for the optimal balance between anti-aging and anti-cancer activities.
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