Hemophagocytic lymphohistiocytosis secondary to Varicella zoster infection in a child with Henoch-Schönlein purpura

Abstract Hemophagocytic lymphohistiocytosis ( HLH ) is a fatal, hyper‐inflammatory syndrome that is characterized by untimely activation of macrophages, and manifests as cytopenia, organ dysfunction, and coagulopathy. Secondary HLH can be associated with infection, drugs, malignancy, and transplantation, and is mostly triggered by infection. Herein, we report the case of a patient with H enoch– S chönlein purpura ( HSP ) who developed severe HLH secondary to V aricella zoster infection.