溶瘤病毒
生物
癌症
病毒
肿瘤微环境
病毒复制
癌细胞
计算生物学
病毒学
癌症研究
生物信息学
作者
Peter J. Mullen,Heather R. Christofk
出处
期刊:Annual review of cancer biology
[Annual Reviews]
日期:2021-12-15
卷期号:6 (1)
标识
DOI:10.1146/annurev-cancerbio-070120-090423
摘要
Viruses are fundamental tools in cancer research. They were used to discover the first oncogenes in the 1970s, and they are now being modified for use as antitumor therapeutics. Key to both of these oncogenic and oncolytic properties is the ability of viruses to rewire host cell metabolism. In this review, we describe how viral oncogenes alter metabolism to increase the synthesis of macromolecules necessary for both viral replication and tumor growth. We then describe how understanding the specific metabolic requirements of virus-infected cells can help guide strategies to improve the efficacy of oncolytic viruses, and highlight immunometabolism and tumor microenvironment research that could also increase the therapeutic benefits of oncolytic viruses. We also describe how studies describing the therapeutic effects of dietary nutrient restriction in cancer can suggest new avenues for research into antiviral therapeutics. Expected final online publication date for the Annual Review of Cancer Biology, Volume 6 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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