Fluoxetine ameliorates Alzheimer’s disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway

神经化学 医学 抗抑郁药 神经保护 单胺类神经递质 内科学 药理学 炎症 内分泌学 氧化应激 神经炎症 氟西汀 海马体 血清素 受体
作者
Karema Abu‐Elfotuh,Aya H. Al-Najjar,Asmaa N. Mohammed,Amany S. Aboutaleb,Ghada A. Badawi
出处
期刊:International Immunopharmacology [Elsevier]
卷期号:104: 108488-108488 被引量:22
标识
DOI:10.1016/j.intimp.2021.108488
摘要

Depression is a risk factor for Alzheimer’s (AD) and cardiovascular diseases (CVD). Therefore, depression treatment restricts its deteriorating effects on mood, memory and CV system. Fluoxetine is the most widely used antidepressant drug, it has neuroprotective effect through its antioxidant/anti-inflammatory properties. The current study investigated for the first-time the cross link between depression, AD and CVD besides, role of fluoxetine in mitigating such disorders. Depression was induced in rats by social isolation (SI) for 12 weeks, AlCL3 (70 mg/kg/day, i.p.) was used to induce AD which was administered either in SI or normal control (NC) grouped rats starting at 8th week till the end of the experiment, fluoxetine (10 mg/kg/day, p.o) treatment also was started at 8th week. SI and AD showed a statistically significant deteriorated effect on behavioral, neurochemical and histopathological analysis which was exaggerated when two disorder combined than each alone. Fluoxetine treatment showed protective effect against SI, AD and prevents exacerbation of CVD. Fluoxetine improved animals’ behavior, increased brain monoamines, BDNF besides increased antioxidant defense mechanism of SOD, TAC contents and increased protein expression of Nrf2/HO-1 with significant decrease of AChE activity, β-amyloid, Tau protein, MDA, TNF-α, IL1β contents as well as decreased protein expression of NF-kB, TLR4, NLRP3 and caspase1. It also showed cardioprotective effects as it improved lipid profile with pronounced decrease of cardiac enzymes of CK-MB, troponin and MEF2. In conclusion, fluoxetine represents as a promising drug against central and peripheral disorders through its anti-inflammatory/antioxidant effects via targeting antioxidant Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathways.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
桐桐应助整齐冬瓜采纳,获得10
刚刚
honghong完成签到 ,获得积分20
1秒前
jjj完成签到,获得积分10
2秒前
慕青应助潇潇雨落采纳,获得10
2秒前
3秒前
悲凉的艳发布了新的文献求助10
3秒前
111完成签到,获得积分10
3秒前
4秒前
最好的发布了新的文献求助10
4秒前
4秒前
丘比特应助爆米花采纳,获得10
5秒前
6秒前
6秒前
星辰大海应助wanzhen采纳,获得10
7秒前
7秒前
HotnessK完成签到,获得积分10
7秒前
简单喀秋莎完成签到,获得积分10
7秒前
阿比盖尔发布了新的文献求助30
8秒前
66完成签到 ,获得积分10
8秒前
酷波er应助顺心绮兰采纳,获得10
8秒前
隐形曼青应助长欢采纳,获得10
9秒前
无辜砖头应助欢呼的念瑶采纳,获得10
9秒前
10秒前
超帅的水壶完成签到,获得积分10
10秒前
木风落完成签到,获得积分10
11秒前
12秒前
ty完成签到,获得积分10
12秒前
DHY发布了新的文献求助10
12秒前
13秒前
似水流年发布了新的文献求助10
13秒前
不理不理左卫门关注了科研通微信公众号
13秒前
yufanhui应助星空采纳,获得10
13秒前
14秒前
14秒前
14秒前
英俊的铭应助坚强莺采纳,获得10
14秒前
天天快乐应助科研通管家采纳,获得10
14秒前
赘婿应助科研通管家采纳,获得10
15秒前
xiaoming应助科研通管家采纳,获得10
15秒前
15秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3135702
求助须知:如何正确求助?哪些是违规求助? 2786585
关于积分的说明 7778267
捐赠科研通 2442686
什么是DOI,文献DOI怎么找? 1298616
科研通“疑难数据库(出版商)”最低求助积分说明 625205
版权声明 600866