Neurogranin: A novel biomarker of Alzheimer’s disease

神经颗粒素 生物标志物 脑脊液 突触可塑性 神经科学 海马体 医学 疾病 认知功能衰退 内科学 心理学 肿瘤科 化学 痴呆 信号转导 受体 生物化学 蛋白激酶C
作者
Maciej Dulewicz,Agnieszka Kulczyńska-Przybik,Aleksandra Klimkowicz‐Mrowiec,Joanna Pera,Renata Borawska,Agnieszka Słowik,Barbara Mroczko
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:17 (S5) 被引量:1
标识
DOI:10.1002/alz.051279
摘要

Abstract Background Alzheimer’s disease (AD) is a progressive, incurable and fatal neurodegenerative disorder characterized by continuing cognitive decline. Early deficits of memory and other cognitive functions has closely related to synaptic loss in AD. Neurogranin (Ng) is a small protein located in postsynaptic neurons, dendrites and spines in brain structures like the hippocampus. Ng plays an crucial role in synaptic plasticity and long‐term potentiation mediated by calcium and calmodulin signalling pathway, which is essential to memory and learning functions. Considering the above mentioned facts, it seems that Ng can be novel biomarker of synaptic injury. The purposes of our investigation were the quantitive assessment of Ng levels in the CSF of AD patients and comparison with classical biomarkers of AD. Method The cerebrospinal fluid (CSF) levels of neurogranin and classical AD biomarkers, such as Aβ‐42, Aβ‐42/Aβ‐40, hTau and pTau181 were assessed by immunoenzyme assays. The study included 15 patients with AD and 15 non‐demented controls. Result The significantly higher concentration of Ng in cerebrospinal fluid of AD patients compared to non‐demented controls was observed. The CSF level of neurogranin was positively correlated with hTau and pTau181 and negatively with Aβ‐42/Aβ‐40 ratio. Conclusion The Ng is a crucial indicator of synaptopathy in the AD.Our results suggest that Ng is a promising biomarker for AD, however, further studies on larger group patients are needed. Acknowledgement: The study was conducted with the use of equipment purchased by the Medical University of Białystok as part of the RPOWP 2007‐2013 funding, Priority I, Axis 1.1, contract No. UDA‐RPPD.01.01.00‐20001/15‐00 dated 26 and project № POWR.03.02.00‐00‐I051/16 from European Union funds, POWER 2014‐2020, grant № 04/IMSD/G/2019
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
打滚完成签到,获得积分10
刚刚
LJJ发布了新的文献求助10
刚刚
睡觉了完成签到 ,获得积分10
2秒前
量子星尘发布了新的文献求助10
3秒前
乖猫要努力应助精明寻梅采纳,获得10
3秒前
AI完成签到,获得积分10
6秒前
xiaosu发布了新的文献求助30
7秒前
7秒前
谢琉圭完成签到,获得积分10
9秒前
领导范儿应助稳重的若雁采纳,获得10
12秒前
12秒前
13秒前
wu完成签到,获得积分20
13秒前
momo发布了新的文献求助10
14秒前
15秒前
田様应助123采纳,获得10
15秒前
19秒前
zying完成签到,获得积分10
22秒前
23秒前
双楠应助wangjue采纳,获得10
23秒前
28秒前
雪白尔岚发布了新的文献求助10
32秒前
32秒前
32秒前
慕青应助momo采纳,获得10
33秒前
从容冰夏完成签到,获得积分10
35秒前
35秒前
桐桐应助Candy采纳,获得10
36秒前
YR完成签到,获得积分10
38秒前
欧阳月空发布了新的文献求助10
38秒前
周em12_发布了新的文献求助10
39秒前
糊涂涂完成签到 ,获得积分10
39秒前
40秒前
42秒前
Zhang完成签到,获得积分10
43秒前
44秒前
44秒前
45秒前
46秒前
圆锥香蕉给ZEcholy的求助进行了留言
47秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173