Neurogranin: A novel biomarker of Alzheimer’s disease

神经颗粒素 生物标志物 脑脊液 突触可塑性 神经科学 海马体 医学 疾病 认知功能衰退 内科学 心理学 肿瘤科 化学 痴呆 信号转导 受体 生物化学 蛋白激酶C
作者
Maciej Dulewicz,Agnieszka Kulczyńska-Przybik,Aleksandra Klimkowicz‐Mrowiec,Joanna Pera,Renata Borawska,Agnieszka Słowik,Barbara Mroczko
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:17 (S5) 被引量:1
标识
DOI:10.1002/alz.051279
摘要

Abstract Background Alzheimer’s disease (AD) is a progressive, incurable and fatal neurodegenerative disorder characterized by continuing cognitive decline. Early deficits of memory and other cognitive functions has closely related to synaptic loss in AD. Neurogranin (Ng) is a small protein located in postsynaptic neurons, dendrites and spines in brain structures like the hippocampus. Ng plays an crucial role in synaptic plasticity and long‐term potentiation mediated by calcium and calmodulin signalling pathway, which is essential to memory and learning functions. Considering the above mentioned facts, it seems that Ng can be novel biomarker of synaptic injury. The purposes of our investigation were the quantitive assessment of Ng levels in the CSF of AD patients and comparison with classical biomarkers of AD. Method The cerebrospinal fluid (CSF) levels of neurogranin and classical AD biomarkers, such as Aβ‐42, Aβ‐42/Aβ‐40, hTau and pTau181 were assessed by immunoenzyme assays. The study included 15 patients with AD and 15 non‐demented controls. Result The significantly higher concentration of Ng in cerebrospinal fluid of AD patients compared to non‐demented controls was observed. The CSF level of neurogranin was positively correlated with hTau and pTau181 and negatively with Aβ‐42/Aβ‐40 ratio. Conclusion The Ng is a crucial indicator of synaptopathy in the AD.Our results suggest that Ng is a promising biomarker for AD, however, further studies on larger group patients are needed. Acknowledgement: The study was conducted with the use of equipment purchased by the Medical University of Białystok as part of the RPOWP 2007‐2013 funding, Priority I, Axis 1.1, contract No. UDA‐RPPD.01.01.00‐20001/15‐00 dated 26 and project № POWR.03.02.00‐00‐I051/16 from European Union funds, POWER 2014‐2020, grant № 04/IMSD/G/2019
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小柒完成签到 ,获得积分10
2秒前
聪慧芷巧发布了新的文献求助10
3秒前
4秒前
8秒前
蓝意完成签到,获得积分0
9秒前
xiaohongmao完成签到,获得积分10
14秒前
17秒前
qweerrtt完成签到,获得积分10
24秒前
24秒前
与共发布了新的文献求助10
25秒前
carly完成签到 ,获得积分10
26秒前
颢懿完成签到 ,获得积分10
29秒前
量子星尘发布了新的文献求助10
30秒前
32秒前
ljc完成签到 ,获得积分10
33秒前
Java完成签到,获得积分10
37秒前
39秒前
鲤鱼安青完成签到 ,获得积分10
41秒前
41秒前
dollarpuff完成签到 ,获得积分10
44秒前
44秒前
mmmmmMM完成签到,获得积分10
51秒前
luckweb完成签到,获得积分10
57秒前
猫的毛完成签到 ,获得积分10
58秒前
nicky完成签到 ,获得积分10
59秒前
麦子完成签到 ,获得积分10
1分钟前
1分钟前
Wilson完成签到 ,获得积分10
1分钟前
luckweb发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
传奇3应助wujiwuhui采纳,获得10
1分钟前
开心寄松完成签到,获得积分10
1分钟前
北宫完成签到 ,获得积分10
1分钟前
wansida完成签到,获得积分10
1分钟前
QXS完成签到 ,获得积分10
1分钟前
1分钟前
菠萝完成签到 ,获得积分10
1分钟前
领导范儿应助Villanellel采纳,获得10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022