清除
二硒醚
结肠炎
化学
抗氧化剂
透明质酸
纳米-
材料科学
纳米技术
生物化学
医学
硒
冶金
复合材料
胃肠病学
解剖
作者
Jiaqi Xu,Tianjiao Chu,Dawei Liu,Naishi Li,Sheng Wang,Chen Li,Yinlong Zhang,Huan Meng,Guangjun Nie
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-07-21
卷期号:16 (8): 13037-13048
被引量:83
标识
DOI:10.1021/acsnano.2c05558
摘要
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel disease (IBD), is responsible for dysregulation of signal transduction, inflammatory response, and DNA damage, which ultimately leads to disease progression and deterioration. Thus, ROS scavenging has become a promising strategy to navigate IBD. Inspired by the targeting capability of hyaluronic acid (HA) to CD44-overexpressed inflammatory cells together with the redox regulation capacity of diselenide compounds, we developed an oral nanoformulation, i.e., diselenide-bridged hyaluronic acid nanogel (SeNG), with a view to treat colitis through a ROS scavenging mechanism. Our data demonstrated that SeNG specifically accumulated in colitis tissue that was mediated by highly efficient CD44-HA interaction. This has allowed us to demonstrate a significant anti-inflammatory effect in an acute colitis mouse model induced by dextran sulfate sodium and trinitrobenzenesulfonic acid. Mechanistically, we continued to show SeNG reduced the ROS level via both direct elimination and up-regulation of the Nrf2/HO-1 signal pathway. Collectively, our work provides proof-of-principle evidence for a SeNG-mediated nano-antioxidant strategy, by which colitis could be effectively managed.
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