化学
废止
迈克尔反应
组合化学
级联
基础(拓扑)
有机化学
立体化学
催化作用
色谱法
数学
数学分析
作者
Qijian Ni,Fangfang Xu,Xiaoxiao Song
标识
DOI:10.1021/acs.joc.2c00448
摘要
An organocatalytic Michael/aza-Michael cascade reaction was developed to build the functionalized quinolizine scaffolds in 60-82% yields, excellent diastereoselectivities, and E/Z selectivities. This protocol involves the [3 + 3] annulations of 2-pyridylacetates with nitroenynes through the dearomative strategy in the presence of an organic base under mild conditions. The versatile late-stage derivatizations further demonstrated the synthetic utility of this methodology.
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