Decreased homotopic functional connectivity in traumatic brain injury

创伤性脑损伤 功能连接 神经科学 心理学 精神科
作者
Reut Raizman,Nofar Itzhaki,Johanna Sirkin,Inbar Meningher,Galia Tsarfaty,Ofer Keren,Zion Zibli,Tamar Silberg,Chaim G. Pick,Abigail Livny
出处
期刊:Cerebral Cortex [Oxford University Press]
卷期号:33 (4): 1207-1216 被引量:4
标识
DOI:10.1093/cercor/bhac130
摘要

Homotopic functional connectivity (HoFC), the synchrony in activity patterns between homologous brain regions, is a fundamental characteristic of resting-state functional connectivity (RsFC).We examined the difference in HoFC, computed as the correlation between atlas-based regions and their counterpart on the opposite hemisphere, in 16 moderate-severe traumatic brain injury patients (msTBI) and 36 healthy controls. Regions of decreased HoFC in msTBI patients were further used as seeds for examining differences between groups in correlations with other brain regions. Finally, we computed logistic regression models of regional HoFC and fractional anisotropy (FA) of the corpus callosum (CC).TBI patients exhibited decreased HoFC in the middle and posterior cingulate cortex, thalamus, superior temporal pole, and cerebellum III. Furthermore, decreased RsFC was found between left cerebellum III and right parahippocampal cortex and vermis, between superior temporal pole and left caudate and medial left and right frontal orbital gyri. Thalamic HoFC and FA of the CC discriminate patients as msTBI with a high accuracy of 96%.TBI is associated with regionally decreased HoFC. Moreover, a multimodality model of interhemispheric connectivity allowed for a high degree of accuracy in disease discrimination and enabled a deeper understanding of TBI effects on brain interhemispheric reorganization post-TBI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
榛糕李发布了新的文献求助10
1秒前
英姑应助鸡腿子采纳,获得10
1秒前
小灰灰发布了新的文献求助10
3秒前
3秒前
3秒前
眼睛大安荷完成签到,获得积分10
4秒前
4秒前
乐乐应助anyelengxin采纳,获得10
4秒前
5秒前
6秒前
领导范儿应助小张采纳,获得10
6秒前
7秒前
7秒前
拼搏山槐发布了新的文献求助10
8秒前
QYPANG发布了新的文献求助10
8秒前
8秒前
Suzanne完成签到,获得积分10
8秒前
CR7应助犬狗狗采纳,获得20
8秒前
卡莎发布了新的文献求助10
8秒前
9秒前
乐乐应助成就的雪莲采纳,获得10
9秒前
榛糕李完成签到,获得积分10
9秒前
CodeCraft应助clocksoar采纳,获得10
9秒前
9秒前
Owen应助科研小白发发发采纳,获得10
10秒前
Curry发布了新的文献求助10
11秒前
Brian发布了新的文献求助10
12秒前
12秒前
13秒前
Rondab应助唐唐采纳,获得10
15秒前
15秒前
标致书易完成签到,获得积分10
15秒前
zx1211发布了新的文献求助10
15秒前
FashionBoy应助平安采纳,获得10
15秒前
哈哈哈发布了新的文献求助10
15秒前
16秒前
16秒前
16秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3958929
求助须知:如何正确求助?哪些是违规求助? 3505199
关于积分的说明 11122925
捐赠科研通 3236708
什么是DOI,文献DOI怎么找? 1788949
邀请新用户注册赠送积分活动 871444
科研通“疑难数据库(出版商)”最低求助积分说明 802794