医学
乳腺癌
化疗
免疫系统
肿瘤微环境
活检
间质细胞
新辅助治疗
病态的
雌激素受体
肿瘤科
癌症
肿瘤浸润淋巴细胞
内科学
病理
免疫疗法
免疫学
作者
Serkan Ilgun,Fatma Aktepe,Oya Güçlü Gönüllü,Nilgun Kapucuoglu,Kanay Yararbas,Gül Alço,Alper Öztürk,Filiz Çelebi,Zeynep Erdogan,Cetin Ordu,Caglar Unal,Tomris Duymaz,Gürsel Soybir,Ekrem Yavuz,Sitki Tuzlali,Vahit Ozmen
出处
期刊:Future Oncology
[Future Medicine]
日期:2022-09-01
卷期号:18 (29): 3289-3298
标识
DOI:10.2217/fon-2022-0157
摘要
Aim: This study investigated the effect of neoadjuvant chemotherapy (NAC) on stromal tumor-infiltrating lymphocytes (sTILs) and their treatment response. Materials & methods: 115 patients with pre-NAC core biopsies and post-NAC surgical resection specimens were reviewed. Results: There was no significant change between pre- and post-treatment sTILs. Both pre- and post-NAC sTILs were significantly lower in patients with luminal A subtype. An increase in sTILs was observed in 21 (25.9%) patients after NAC, a decrease in 29 (35.8%) and no change in 31 (38.3%; p = 0.07). Pretreatment sTIL density was independent predictor of pathological complete response in multivariate analyses (odds ratio: 1.025, 95% CI: 1.003-1.047; p = 0.023). Conclusion: High sTIL density in core biopsies was independently related to pathological complete response. In addition, ER appears to be the most crucial factor determining the rate of sTIL.New studies have shown that the tumor microenvironment is critical in tumor behavior. Immune cells surrounding tumor cells are the main components of the tumor microenvironment. Our study aimed to investigate the change in immune cells before and after chemotherapy in breast cancer patients. Our study included 115 patients. All patients underwent chemotherapy before surgery to shrink the tumor. Tru-cut biopsy pieces and the breast tissue obtained after surgery were examined. The presence of estrogen or progesterone receptors on tumor cells decreased the number of immune cells surrounding the tumor cells. The number of immune cells did not decrease after chemotherapy. Another finding was that the greater the number of immune cells around the tumor, the more likely that the tumor would disappear after chemotherapy.
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