谷胱甘肽
化学
药物输送
阿霉素
癌细胞
生物物理学
胱氨酸
半胱氨酸
氧化还原
细胞内
药品
纳米技术
生物化学
材料科学
药理学
癌症
生物
化疗
有机化学
酶
遗传学
作者
Suman Nayak,Kiran Das,Subramaniyam Sivagnanam,Shyamvarnan Baskar,Adele Stewart,Dinesh Kumar,Biswanath Maity,Priyadip Das
出处
期刊:iScience
[Elsevier]
日期:2024-04-01
卷期号:27 (4): 109523-109523
标识
DOI:10.1016/j.isci.2024.109523
摘要
Fabrication of stimuli-responsive superstructure capable of delivering chemotherapeutics directly to the cancer cell by sparing healthy cells is crucial. Herein, we developed redox-responsive hollow spherical assemblies through self-assembly of disulfide-linked cysteine-diphenylalanine (SN). These fluorescent hollow spheres display intrinsic green fluorescence, are proteolytically stable and biocompatible, and allow for real-time monitoring of their intracellular entry. The disulfide bond facilitates selective degradation in the presence of high glutathione (GSH) concentrations, prevalent in cancer cells. We achieved efficient encapsulation (68.72%) of the anticancer drug doxorubicin (Dox) and demonstrated GSH-dependent, redox-responsive drug release within cancerous cells. SN-Dox exhibited a 20-fold lower effective concentration (2.5 μM) for compromising breast cancer cell viability compared to non-malignant cells (50 μM). The ability of SN-Dox to initiate DNA damage signaling and trigger apoptosis was comparable to that of the unencapsulated drug. Our findings highlight the potential of SN for creating site-specific drug delivery vehicles for sustained therapeutic release.
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