Finite element analysis of repairing tympanic membrane perforation using autologous graft material and biodegradable bionic cobweb scaffold

镫骨 材料科学 颞筋膜 软骨 有限元法 鼓膜穿孔 穿孔 生物医学工程 筋膜 中耳 鼓室成形术 外科 医学 复合材料 解剖 结构工程 冲孔 工程类
作者
Liang Wang,Hongge Han,Jie Wang,Ying Zhu,Zhanli Liu,Yongtao Sun,Xun Hu,Shuyi Xiang,Huibin Shi,Qi Ding
出处
期刊:Computer Methods and Programs in Biomedicine [Elsevier]
卷期号:243: 107868-107868
标识
DOI:10.1016/j.cmpb.2023.107868
摘要

As for repairing the perforated tympanic membranes (TM), temporalis fascia and tragal cartilage are popular in clinics as autologous graft materials. However, there is a significant hearing loss after repairing the TM with autologous graft materials, which needs to be addressed in biomechanical engineering. the repair method of tympanic fibrous layer and the bionic spider web tympanic scaffold. By creating the solid-shell coupling condition and strong coupling boundary condition to simulate the repair, TM umbo and stapes footplate displacement-frequency response are explored in 200-8000 Hz. The tympanic membrane perforation (TMP) causes a significant conductive hearing loss in high frequency region, which is positively correlated with perforation area. Both temporalis fascia and tragal cartilage still perform a certain degree of high-frequency hearing loss after repairing TMP. The TM attachment the magnesium alloy scaffold (MAS) prevents appropriately the high frequency hearing loss after autologous graft repair and makes the sound transmission closer to the normal condition. Significantly, the density of graft material has a negative effect on high-frequency sound transmission without the MAS. The modal-motion of TM repaired with temporalis fascia and tragal cartilage is improved significantly after attaching the MAS. In addition, the MAS restores effectively the configuration and vibration frequency of the repaired TM, which is similar to that of the native TM. The area size of TMP is studied through the finite element method, which includes autologous graft materials, the MAS, parameter sensitivity analysis, modal analysis of graft material and the MAS in biological form on the effect of middle ear sound transmission. Relevant conclusions provide some references for clinical trial protocol and the follow-up repair ideas of TM of tympanoplasty.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
刚刚
搞对完成签到,获得积分10
刚刚
小白杨完成签到,获得积分10
刚刚
刚刚
李爱国应助咕噜噜采纳,获得10
刚刚
烂漫的白薇完成签到,获得积分10
1秒前
小蘑菇应助失眠的以蓝采纳,获得10
1秒前
joker_k完成签到,获得积分10
1秒前
大个应助枫凝静影采纳,获得10
1秒前
GGblue完成签到,获得积分10
2秒前
whiteandpink098完成签到,获得积分10
2秒前
ikun发布了新的文献求助10
2秒前
hyaoooo发布了新的文献求助10
2秒前
亮皮鱼老大完成签到,获得积分10
2秒前
maox1aoxin应助小王采纳,获得30
3秒前
淡然夏柳完成签到,获得积分20
3秒前
LLLLLL完成签到,获得积分20
3秒前
4秒前
4秒前
徐小发布了新的文献求助10
4秒前
4秒前
打打应助yyyf采纳,获得10
4秒前
Hello应助吴陈采纳,获得10
4秒前
酒仙发布了新的文献求助10
5秒前
6秒前
ncwgx完成签到,获得积分10
6秒前
悠咪发布了新的文献求助10
6秒前
7秒前
淡然夏柳发布了新的文献求助20
7秒前
7秒前
8秒前
科研通AI5应助xxxxx采纳,获得10
8秒前
小赵赵赵发布了新的文献求助30
9秒前
9秒前
zhyubo7完成签到,获得积分10
9秒前
fannyeast完成签到,获得积分10
9秒前
重要的莫茗完成签到,获得积分10
9秒前
大牛子完成签到,获得积分10
9秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546888
求助须知:如何正确求助?哪些是违规求助? 3123917
关于积分的说明 9357332
捐赠科研通 2822504
什么是DOI,文献DOI怎么找? 1551513
邀请新用户注册赠送积分活动 723546
科研通“疑难数据库(出版商)”最低求助积分说明 713791