肿瘤微环境
卵巢癌
PLGA公司
癌症研究
癌细胞
化疗
纳米医学
癌症
医学
材料科学
药理学
内科学
纳米技术
纳米颗粒
作者
Mingzhuang Li,Yingyao Wang,Lin Zhang,Qin Liu,Feizhou Jiang,Wenjie Hou,Yudong Wang,Huapan Fang,Yueming Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-08-21
卷期号:17 (17): 16703-16714
被引量:12
标识
DOI:10.1021/acsnano.3c03013
摘要
The aberrant tumor microenvironment (TME), especially immature and leaky vessels, prevents the penetration and accumulation of chemotherapeutics and results in the failure of chemotherapy to treat gynecologic cancer. Herein, dexamethasone (Dex), a glucocorticoid steroid used to moderate tumor extracellular matrix and normalize vessels, was enclosed within a biocompatible material known as poly(lactic-co-glycolic acid) (PLGA), and the obtained Dex@PLGA was further coated with a mouse cervical cancer cell membrane (CM). The formulated Dex@PLGA-CM nanoparticles showed efficient extravascular diffusion within the tumor owing to the homologous targeting abilities inherited from the source cancer cells. The Dex@PLGA-CM nanoparticles greatly reshaped the TME, enhancing the penetration of Doxil and thus markedly improving the therapeutic effect of this drug against cervical cancers. Excitingly, the Dex@PLGA-CM nanoparticles coated with mouse ovarian cancer cell membranes also promoted Doxil-mediated chemotherapy effects in metastatic ovarian cancer when administered intraperitoneally. This work presents an effective nanomedicine for the efficient modification of the TME to enhance the effects of gynecologic cancer chemotherapy.
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