自愈水凝胶
软骨
再生(生物学)
细胞外基质
软骨发生
生物医学工程
组织工程
材料科学
生物相容性
解剖
细胞生物学
医学
生物
高分子化学
冶金
作者
Lihui Sun,Xu Yan,Yu Han,Jing Cui,Jing Zheng,Dongbo Li,Jianguo Liu,Chunsheng Xiao,Dongsong Li,Bo Cai
摘要
Cartilage regeneration remains difficult due to a lack of blood vessels. Degradation of the extracellular matrix (ECM) causes cartilage defects, and the ECM provides the natural environment and nutrition for cartilage regeneration. Until now, collagen hydrogels are considered to be excellent material for cartilage regeneration due to the similar structure to ECM and good biocompatibility. However, collagen hydrogels also have several drawbacks, such as low mechanical strength, limited ability to induce stem cell differentiation, and rapid degradation. Thus, there is a demanding need to optimize collagen hydrogels for cartilage regeneration. In this review, we will first briefly introduce the structure of articular cartilage and cartilage defect classification and collagen, then provide an overview of the progress made in research on collagen hydrogels with chondrocytes or stem cells, comprehensively expound the research progress and clinical applications of collagen‐based hydrogels that integrate inorganic or organic materials, and finally present challenges for further clinical translation.
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