The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

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作者
Lu Ma,Xin Hu,Lili Song,Xiaoying Chen,Menglu Ouyang,Laurent Billot,Qiang Li,Alejandra Malavera,Xi Li,Paula Muñoz Venturelli,Asita de Silva,Nguyen Huy Thang,Kolawole Wahab,Jeyaraj Pandian,Mohammad Wasay,Octávio Marques Pontes‐Neto,Carlos Abanto,Antonio Araúz,Haiping Shi,Guanghai Tang,Sheng Zhu,Xiaochun She,Leibo Liu,Yuki Sakamoto,Shoujiang You,Qiao Han,Bernard Crutzen,Emily Cheung,Yunke Li,Xia Wang,Chen Chen,Feifeng Liu,Yang Zhao,Hao Li,Yi Liu,Yan Jiang,Lei Chen,Bo Wu,Ming Liu,Jianguo Xu,Chao You,Craig S. Anderson,Thompson Robinson,J. Jaime Miranda,Craig S. Anderson,Chao You,Lili Song,Adrian Parry‐Jones,Nikola Sprigg,S. F. Durrans,Caroline Harris,Ann Bamford,Olivia Smith,Robert J. Herbert,Christopher Chen,William Whiteley,Rong Hu,Laurent Billot,Qiang Li,Jayanthi Mysore,Xin Hu,Yao Zhang,Feifeng Liu,Yuki Sakamoto,Shoujiang You,Qiao Han,Bernard Crutzen,Yunke Li,Emily Cheung,Stephen Jan,Hueiming Liu,Menglu Ouyang,Lingli Sun,Honglin Chu,Anila Anjum,Francisca Gonzalez Mc Cawley,Alejandra Del Rio,Bruna Rimoli,Rodrigo Cerantola,Thanushanthan Jeevarajah,Madhushani Kannangara,Andrene Joseph,Chamath Nanayakkara,Xiaoying Chen,Alejandra Malavera,Chunmiao Zhang,Zhao Yang,Brook Li,Zhuo Meng,Menglu Ouyang,Leibo Liu,Yi Ning,Le Dong,Manuela Armenis,Joyce Lim,Helen Monaghan,Lu Ma,Xin Hu,Zhiheng Li,Rui Luo,Guojuan Cheng,Yilin Dong,Ziqin Liu,Shuihong Wang,Ying Zhang,J.P. Cheng,Hui Shi,Wenjing Li,Langming Mou,Ping Yi,Chen Chen,X Chen,Shalomi Weerawardena,Poornima Ellawala,Enalee Ranasinghe,C Caniego Rodrigo,Kolawala Wahab,Sunday Adeniyi,Jeyaraj Pandian,Megha Khanna,Paula Muñoz Venturelli,Francisca González,Francisca Urrutia Goldsack,Mohammad Wasay,Dilshad Begum,Anila Anjum,Octávio Marques Pontes‐Neto,Millene Rodrigues Camilo,Francisco Antunes Dias,Octavio Vincenzi,Rodrigo Cerantola,Carla Heloísa Cabral Moro,Renata Santos,Nara Texeira,Alexandre Luiz Longo,Rafaela B. Liberato,Sheila Cristina Ouriques Martins,Arthur Pille,Bruna Cristine Chwal,Isabel Silva,N.F. Titton,Gustavo Weiss,Daissy Mora,Magda Ouriques,Leonardo Augusto Carbonera,Rodrigo Bazán,Gabriel Pinheiro Módolo,Fernanda Cristina Winckler,Luana Miranda,Juli Thomaz de Souza,Alexis Rojo,Wilhelm Uslar,Lorena Medel,Javiera López,D. Herrero,Pablo M. Lavados,Barbara Vargas Latorre,Nathalie Conejan,Tomás Esparza,Patricio Sotomayor,Denisse Wenger,Juan Pablo Gigoux,Aldo Letelier,Lilian Acevedo,Vivianne Moya,Cristian Figueroa,N. Vallejos,Nathalie Conejan,Tomás Esparza,Patricio Sotomayor,Rodrigo Guerrero,Mauricio Velásquez,José Vallejos,Kimerly Pallauta,Tamara Santibanez,Angelo Queirolo,A.-T. Lobos,Yongming Jiang,Weimin Li,Wei Huang,Ke Luo,G Liu,Guanghai Tang,Guang Yang,Hongtao Jiang,Xu Zhang,Hongyan Jing,Sheng Zhu,Bo Pu,Dong Lv,Hui Kang,Qiuping Hu,Xiaochun She,Xiaoming Jiang,Yanli Chen,Sheng‐Hua Yang,Jianjun He,Zongping Li,Gang Cheng,Hailin Huang,Xiaoyi Wang,Jianqiong Lin,Minhui Chen,Chenghao Yang,Hao Ding,Yunliang Deng,Fei Luo,Rongjun Zhang,Xiaofeng Wang,Hongbing Zhang,Xiaoliang Yang,Yang Zhang,Chengyi Yang,Yu He,Feng Liu,Rongjie Wang,Yuhui Zhang,Xiaodong Xin,Bin Feng,Wanru Hao,Chang Eun Song,Yun Guo,Dehua Jiang,Jie Chen,Changtong Tang,Hongliang Zhu,Xin Li,Jin Cui,Haidong Xu,Boyang Li,Fusheng Tang,Yuanbin Li,Min Gao,Bo Yang,Xuejun Xu,Bing Deng,Yi Zheng,Yuanhong Ge,Keyu Chen,Yang Liu,Xinshen Li,Tingting Zhong,Jianfeng Xu,Zhang Hai,Jiyue Wang,Jian‐Xin Zhu,Hanyu Sun,YU Fu-hua,Xueguang Zhang,Chao You,Lu Ma,Xin Hu,Jianguo Xu,Zhiheng Li,Mingsen Zhang,Bin Wang,Yiming Ma,Donglin Jiang,Jun Zhou,Cong Liu,Wenhong Nie,Mingguo Li,Tao Tian,Y Li,Mingfang He,Xiaolong Tu,Zhengjun Wu,Hong Liu,Dongsheng Zhong,Rongcai Jiang,Jian Sun,Ye Tian,Yingsheng Wei,Shuo An,Pingbo Wei,Le Luo,Bin Lin,Gang Liu,Yan Wen,Qiang Cai,Qianxue Chen,Lei Pan,Zhiyang Li,Meifang Zhang,Jiaquan He,Yan Chen,Jun Liu,Xing‐Hai Liu,Junyan Li,Min Chen,Jing Wang,Bingzhi Zhou,Baichun Ye,Jiancheng Zhang,Manyuan Zhang,Xuming Pan,Xiaoxiang Yu,Jian Xu,Qingbao Xiao,Yuefei Wang,Tao Liang,Shi Lin,Niandong Zheng,Guoliang You,Bo Lei,Shu Chen,Honggang Wu,Hu Jin,Jian‐Lan Zhao,Jian Yu,Qiang Yuan,Zhuoying Du,Xielin Tang,Qianke Li,Shenghua Liu,Feilong Yang,Kui Xiao,Chao Luo,Guang Wang,Xudong Che,Zhipeng Teng,Wenwu Wan,Jun Li,Yu Liu,Mingbo Fan,Tao Zhang,Lun Cai,Yuan Ma,Zhifeng Ma,Bin Li,Linlin He,Jinghui Li,Weibing Zhang,Shuxin Zhang,Hongzhen Zhang,Yingguang Dai,Lei Jun,Lei Mao,Yiyang Huang,Zhiguang Zhou,Ping Chen,Fang Chen,Wei Pan,Tiangui Li,Honglin Chen,Mengfei Zeng,Kejie Mou,Jun Xue,Yong Jiang,Xiaoping Tang,Tao Chen,Yalan Zhang,Yanbing Xu,Yuchen Gu,Lei Chen,Yu‐Jun Zhao,Bin Yang,Peng Kuai,Yinglin Wang,Yuwang Yang,Xueling Hu,Huitian Zhang,Yintao Yang,Weifeng Wang,Junyi Zhang,Wei Cheng,Xiaoxue Zhang,Xiaowen Ma,Qin He,Li Zhang,Rong Gao,Huixiang Liu,Jingwei Ye,Ping Xu,Xin Wu,Yuan Yuan,Peng Zou,Zhen Zhang,Jiyong Cheng,Zhangming Zhou,Yijun Zeng,Liang Zhang,Deming Du,Shui Yu,Yongjun Cao,Shoujiang You,Jiaping Xu,Zhichao Huang,Dongqin Chen,Wenfeng Xiao,Li Zhu,Yuan Miao,Yuhai Wang,Dongliang Shi,Xu Hu,Dingchao Xiang,Like Shi,Hong‐Qin Wang,Liu Yang,Miao Wang,Yiyi Hu,Yuchun Zhao,Xi Hu,Yang Liu,Weiduo Zhou,Chao Sun,Tao Chen,Tang Dong,Kun Yao,Jin Jong You,Shishi Chen,Jian-min Yao,Huanmei Li,Jinmei Liu,Ailin Bai,Yong Yi,Qingshan Deng,Peng Luo,Han Wang,Jingcheng Jiang,Qingwei Yang,Shunpo He,Jun Wang,Yong‐Min Liang,Hua He,Yuyang Deng,Zhikai Cao,Xuxia Yi,Jinbiao Luo,Shuang Luo,Min Gong,Li C. 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出处
期刊:The Lancet [Elsevier]
卷期号:402 (10395): 27-40 被引量:123
标识
DOI:10.1016/s0140-6736(23)00806-1
摘要

Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols for early intensive blood pressure lowering and management algorithms for hyperglycaemia, pyrexia, and abnormal anticoagulation, implemented in a hospital setting, could improve outcomes for patients with acute spontaneous intracerebral haemorrhage.
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