体内分布
生物
放射生物学
核医学
放射治疗
医学物理学
癌症研究
医学
内科学
体内
生物技术
作者
Edward K. Fung,Pat Zanzonico
标识
DOI:10.1016/bs.mcb.2023.02.012
摘要
Radiopharmaceutical therapy is a rapidly growing field for the treatment of cancer due to its high specificity and ability to target individual affected cells. A key component of the pre-clinical development of a new therapeutic radiopharmaceutical is the determination of its time-dependent distribution in tumors, normal tissues, and the whole body in mouse tumor models. Here, we provide an overview of the available instrumentation for the novice in radiation measurement. We also detail the methodology for assessing distribution and kinetics of a radiopharmaceutical and calculating radiation absorbed dose in mice using a gamma counter or a PET or SPECT camera.
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