甘露聚糖
生物
聚糖
细菌
生物化学
微生物学
寄主(生物学)
肠道菌群
计算生物学
多糖
糖蛋白
遗传学
作者
Deepesh Panwar,A. Shubhashini,M. Kapoor
标识
DOI:10.1016/j.biotechadv.2023.108166
摘要
The human gut microbiota (HGM), a community of trillions of microbes, underscores its contribution by impacting many facets of host health and disease. In the HGM, Bacteroidota and Bacillota represent dominant bacterial phyla, which mainly rely on the glycans recalcitrant to host digestion to meet their energy requirements. Accordingly, the impact of dietary and host-derived glycans in the assembly and operation of these dominant microbial communities continues to be an area of active research. Among various glycans, mannans represent an integral component of the human diet. Apart from their health effects, the diverse and complex mannan structures bears molecular signatures that alter the expression of specific gene clusters in selected Bacteroidota and Bacillota species. Both the phyla possess variable and sophisticated loci of mannan sensing proteins, hydrolytic enzymes, transporters, and other metabolic proteins to sense, capture and utilize mannans as an energy source. The current review summarizes mannan structural diversity, and strategies opted by select bacterial species of the HGM to forage mannans by focusing primarily on glycoside hydrolases and their effects on host health and metabolism.
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