孟德尔随机化
医学
焦虑
萧条(经济学)
肠道菌群
广泛性焦虑症
精神科
随机化
临床心理学
随机对照试验
内科学
遗传学
免疫学
基因
生物
基因型
宏观经济学
经济
遗传变异
作者
Tianyue Fan,Lingxiao Li,Yi Chen
出处
期刊:PubMed
日期:2024-09-06
卷期号:103 (36): e39543-e39543
标识
DOI:10.1097/md.0000000000039543
摘要
Evidence shows that the composition of the gut microbiota (GM) is associated with depression and anxiety disorders. However, the causal relationship between them remains controversial. To investigate the potential causal relationship between the GM and depression/anxiety disorders and to identify specific bacterial taxa, we conducted a 2-sample Mendelian randomization (MR) analysis on the gut microbiome implicated in depression and anxiety disorders. We incorporated summary data from genome-wide association studies (GWAS) of the microbiome derived from 7738 individuals in the Dutch Microbiome Project and 18,340 individuals in the MiBioGen consortium as our exposure variable. Concurrently, the GWAS of depression and anxiety disorders was employed as our outcome variable. The principal estimates were procured using the inverse-variance weighted test complemented by 4 robust methods: MR Egger, weighted median, simple mode, and weighted mode. In addition, we performed comprehensive sensitivity and directionality analyses. The results showed that 5 bacterial taxa were positively correlated with depression, 6 were negatively correlated; 5 were positively correlated with anxiety disorders, and 11 were negatively correlated. This study provides new insights into the connection between the GM and the pathogenesis of depression and anxiety disorders and offers new perspectives for the diagnosis and treatment of these disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI