柠檬酸循环
能量代谢
医学
小胶质细胞
新陈代谢
氧化磷酸化
痛觉超敏
痛觉过敏
糖酵解
感觉
神经科学
细胞代谢
伤害
细胞生物学
生物信息学
生物
炎症
生物化学
内分泌学
内科学
受体
作者
Xiongjuan Li,Zhao Zhao,Yuebin Ke,Yonghan Jiang,Yuqiang Liu,Zhiheng Liu
标识
DOI:10.1213/ane.0000000000007096
摘要
One of the functions of organism cells is to maintain energy homeostasis to promote metabolism and adapt to the environment. The 3 major pathways of cellular energy metabolism are glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (OXPHOS). Neurons, astrocytes, and microglia are crucial in allodynia, hyperalgesia, and sensitization in nociceptive pathways. This review focused on these 3 major cellular energy metabolism pathways, aiming to elucidate the relationship between neurocyte and pain sensation and present the reprogramming of energy metabolism on pain, as well as the cellular and molecular mechanism underlying various forms of pain. The clinical and preclinical drugs involved in pain treatment and molecular mechanisms via cellular energy metabolism were also discussed.
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