化学
电子供体
电子
电子受体
光化学
接受者
组合化学
有机化学
催化作用
物理
量子力学
凝聚态物理
作者
Wei Liu,Hao Hou,Haochuan Jing,Shiqing Huang,Wei Ou,Chenliang Su
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-07-11
卷期号:26 (29): 6092-6097
标识
DOI:10.1021/acs.orglett.4c01673
摘要
β-Amino nitriles are important molecular scaffolds. Cyanoalkylation of imines is the most straightforward method for the construction of these scaffolds. In this study, we report the novel cyanoalkylation of imines via radical coupling enabled by a photoactive electron donor-acceptor complex. This strategy is characterized by mild conditions, broad reaction scopes, and high atom economy. The scalability and practicality of this strategy are demonstrated by a 40 g continuous flow system from which a variety of important pharmaceutical-related molecules were obtained.
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