Co-metabolism of microorganisms: A study revealing the mechanism of antibiotic removal, progress of biodegradation transformation pathways

The widespread use of antibiotics has resulted in large quantities of antibiotic residues entering aquatic environments, which can lead to the development of antibiotic-resistant bacteria and antibiotic-resistant genes, posing a potential environmental risk and jeopardizing human health. Constructing a microbial co-metabolism system has become an effective measure to improve the removal efficiency of antibiotics by microorganisms. This paper reviews the four main mechanisms involved in microbial removal of antibiotics: bioaccumulation, biosorption, biodegradation and co-metabolism. The promotion of extracellular polymeric substances for biosorption and extracellular degradation and the regulation mechanism of enzymes in biodegradation by microorganisms processes are detailed therein. Transformation pathways for microbial removal of antibiotics are discussed. Bacteria, microalgae, and microbial consortia's roles in antibiotic removal are outlined. The factors influencing the removal of antibiotics by microbial co-metabolism are also discussed. Overall, this review summarizes the current understanding of microbial co-metabolism for antibiotic removal and outlines future research directions.